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Nouvelle publications étude SeroMed: taux de seroprevalence du virus Toscana en Corse

Une nouvelle étude issue du projet de recherche SeroMed vient d'etre publiée

Open Access

Viruses 2019, 11(9), 817; https://doi.org/10.3390/v11090817

Circulation of Toscana Virus in a Sample Population of Corsica, France
1Université de Corse Pascal Paoli, EA7310 BIOSCOPE, 20250 Corte, France
2Unité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13385 Marseille, France
3Sciences Pour l’Environnement—UMR CNRS 6134, Université de Corse, 20250 Corte, France
*Correspondence: masse_s@univ-corse.fr; Tel.: +33-420-202-219; Fax: +33-420-202-392


Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to investigate the seroprevalence of TOSV and SFSV antibodies in a healthy population from Corsica. In this cross-sectional study, participants were enrolled (i) from a medical staff at the University of Corsica and (ii) from general practitioners of the Corsican Sentinelles Network. The seroprevalence study was based on a virus microneutralization assay. A total of 240 sera were tested. Altogether, 54 sera (22.5%) were confirmed positive for TOSV antibodies, whereas none were positive for SFSV (0/240). The residential district of participants was significantly associated with TOSV seropositivity (p value = 0.005). The rate of the seropositivity against TOSV in our study suggests that the Corsican population is well exposed to the TOSV. These results encourage the implementation of a systematic surveillance system including entomological, microbiological, and medical aspects for the collection of better information on the diseases that are associated with phleboviruses in Corsica and beyond in the regions where these viruses are present.
Sandfly Fever Sicilian virus; seroprevalence; microneutralization; meningitis; arbovirus; arthropod-borne virus; Phlebovirus; Phenuiviridae; Bunyavirales; sandfly
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