EA Bioscope Corse Méditerranée | Dynamique des infections en milieu insulaire
Maladies émergentes : données en Corse issues de l’étude Seromed  |
Circulation du virus de l'hépatite E en Corse: nouvelle publication

 

2019 Jul 23. doi: 10.1111/tbed.13304. [Epub ahead of print]

Drastic decline of hepatitis E virus detection in domestic pigs after the age of 6 months, Corsica, France.

Author information

1
EA 7310, Laboratoire de Virologie, Université de Corse, Corte, France.
2
Laboratoire de Recherche sur le Développement de l'Elevage (LRDE), Institut National de la Recherche Agronomique (INRA), Corte, France.
3
Sciences Pour l'Environnement - UMR CNRS 6134, niversité de Corse, Corte, France.
4
IRD 190, INSERM 1207, IHU Méditerranée Infection, Unité des Virus Émergents (UVE): Aix Marseille Univ, Marseille, France.
5
Emerging Pathogens Institute, University of Florida, Gainesville, Florida.

Abstract

Suidae is an important reservoir of hepatitis E virus (HEV) and a source of transmission to humans (direct contact or via consumption of meat products). Our goal was to characterize the epidemiology of HEV infecting domestic pigs in Corsica Island, a French region hyperendemic for HEV. In Corsica, traditional extensive (or semi-extensive) outdoor pig farming system is common. Sixteen farms were selected according to location and breeding system. Individual pig faeces samples were collected and qRT-PCR for detecting HEV RNA was performed. Nucleic acids from HEV-positive samples were amplified using specific ORF2 genotyping system. The genotype and subtype of the Corsican HEV sequences were determined by phylogenetic analysis. Among the 919 porcine faeces samples tested 9.2% (n = 85) were positive. The presence of viral RNA was correlated with (a) age (>6 months) Adjusted Odd Ratio (AOR) 0.25 [0.068-0.90] p = .032; 3-4 months AOR = 4.94 [2.30-10.62] p = .000043) with the logistic regression model with a random effect at the farm level. Among the 85 positive samples, 83 belonged to genotype 3c and two to genotype 3f. The highest prevalence was observed in the 3-4 months age group and older age (>6 months) was negatively related to HEV infection and this suggests that traditional breeding with a late slaughter age may limit the risk of transmission to humans. A kinetic study of pigs from birth to slaughtering would allow to ensure that the type of traditional breeding reported here is very favourable to the absence of the virus in slaughtered pigs and in pork products.

 

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